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TESAMORELIN 10MG - Image 1

TESAMORELIN 10MG

Tesamorelin is a stabilized synthetic analog of human growth hormone-releasing hormone (GHRH). It is specifically researched for its ability to reduce visceral adipose tissue (excess abdominal fat) in certain metabolic conditions.

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Original price was: $125.00.Current price is: $88.00.

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The information provided on this page is intended solely as a general summary. It does not encompass all potential research applications, handling procedures, safety precautions, interactions, or observed effects. These products are supplied strictly for laboratory and research purposes only. They are not intended for human consumption, medical use, veterinary use, or diagnostic purposes. This information must not be considered a substitute for professional expertise, judgment, or regulatory guidance.

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SEQUENCE/FORMULA

Sequence: trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-AsnSer-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-LeuGln-Asp-Ile-Met-Ser-Arg-GlnGln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu Molecular Formula: C221H366N72O67S

MOLECULAR WEIGHT

5136 g/mol

PUBCHEM CID

16137936
  • Studying its targeted effects on reducing stubborn abdominal fat
  • Investigating its role in improving cholesterol and blood sugar markers
  • Analyzing its potential to support cognitive function during aging
  • Researching its effects on liver health and fat reduction
  • Exploring its potential to support nerve health and repair
  • Tesamorelin is a stabilized synthetic analogue of Growth Hormone-Releasing Hormone (GHRH).
  • It works by binding to and stimulating GHRH receptors in the anterior pituitary gland. This action mimics the body's natural GHRH, prompting the synthesis and pulsatile release of endogenous growth hormone (GH).
  • The released GH then acts on various tissues, primarily stimulating the liver to produce insulin-like growth factor 1 (IGF-1).
  • The therapeutic effect for lipodystrophy stems from the potent lipolytic (fat-burning) action of GH, which preferentially targets visceral fat stored around the internal organs.
  • The modification at its N-terminus protects the peptide from rapid breakdown by the DPP-4 enzyme, giving it a longer half-life than naturally occurring GHRH.
  • Falutz, J., et al. (2007). Effects of Tesamorelin (TH9507), a Growth Hormone–Releasing Factor Analog, in HIV-Infected Patients with Abdominal Fat Accumulation. The New England Journal of Medicine, 357(23), 2349-2360.
  • Stanley, T. L., et al. (2014). Effects of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical Trial. JAMA, 312(4), 380–389.
  • Baker, L. D., et al. (2018). Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment. JAMA Neurology, 75(11), 1369–1377.
  • Adrian, S., & Scherzinger, A. (2018). Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy. Expert Review of Clinical Pharmacology, 11(8), 751-759.