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THYMOSIN ALPHA-1 5MG

Thymosin Alpha 1 is a potent peptide hormone that plays a crucial role in regulating the human immune system. Originally isolated from the thymus gland, it is a naturally occurring component of the body’s defense mechanism. Comprised of 28 amino acids, this peptide is known for its ability to enhance and modulate immune responses, particularly by stimulating the activity of T-cells, which are vital for identifying and destroying infected or cancerous cells.

Its ability to bolster the immune system has made Thymosin Alpha 1 a subject of intense scientific and clinical interest for decades. It is used and investigated as a therapeutic agent for a variety of conditions where a robust immune response is needed, including chronic viral infections, certain types of cancer, and as an adjunct to vaccines to improve their effectiveness.

Specifications:
• Quantity: 5mg
• Storage: -20°C, lyophilized
• Purity: >99% (HPLC)

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$75.00

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The information provided on this page is intended solely as a general summary. It does not encompass all potential research applications, handling procedures, safety precautions, interactions, or observed effects. These products are supplied strictly for laboratory and research purposes only. They are not intended for human consumption, medical use, veterinary use, or diagnostic purposes. This information must not be considered a substitute for professional expertise, judgment, or regulatory guidance.

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SEQUENCE/FORMULA

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Molecular Formula:

MOLECULAR WEIGHT

3108.3 g/mol  

PUBCHEM CID

16132172
  • Hepatitis Treatment: Analyzing its effectiveness in treating chronic hepatitis B and C by enhancing the body's viral clearance capabilities.
  • Oncology: Researching its role as an adjunct therapy for various cancers, including melanoma and liver cancer, to help the immune system better target and fight tumor cells.
  • Immunodeficiency Disorders: Studying its potential to restore immune function in patients with suppressed or deficient immune systems.
  • Vaccine Adjuvant: Exploring its use to boost the immune response to vaccines, potentially leading to stronger and longer-lasting immunity, particularly in elderly or immunocompromised individuals.
  • Sepsis and Infections: Investigating its ability to help control severe infections and sepsis by modulating the inflammatory response and improving immune cell function.
Thymosin Alpha 1 primarily works by interacting with toll-like receptors (TLRs), particularly TLR9 and TLR2, on the surface of immune cells like dendritic cells and T-cells. This interaction triggers a cascade of signaling events within the cells. A key outcome is the maturation of dendritic cells, which are responsible for presenting antigens to T-cells. By promoting this process, Thymosin Alpha 1 helps activate and increase the proliferation of cytotoxic T-cells (CD8+) and helper T-cells (CD4+). These T-cells are then better equipped to seek out and eliminate virally infected cells and malignant cells. It also helps balance the immune response, preventing excessive inflammation.
  • Goldstein, A. L., Low, T. L., McAdoo, M., McClure, J., Thurman, G. B., Rossio, J., ... & Schulof, R. S. (1977). Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. Proceedings of the National Academy of Sciences, 74(2), 725-729.
  • Lian, Z., Liu, J., & Zhang, Z. (2010). A review of the clinical and experimental applications of thymosin α1. Journal of Cellular and Molecular Medicine, 14(4), 780-788.
  • Tuthill, C., Rios, I., & McBeath, R. (2018). Thymosin alpha 1: A comprehensive review of the literature. Expert Opinion on Drug Metabolism & Toxicology, 14(12), 1275-1287.
  • Dominari, A., Hathaway, III, D., Pandav, K., Matos, W., & Biswas, S. (2020). The role of thymosin alpha 1 in the treatment of COVID-19. International Journal of Infectious Diseases, 100, 368-372.