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MOTS-C

MOTS-c is a mitochondrial-derived peptide known for its role in metabolic regulation. It is researched for its effects on insulin sensitivity, cellular energy homeostasis, and exercise capacity.

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Price range: $70.00 through $150.00

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The information provided on this page is intended solely as a general summary. It does not encompass all potential research applications, handling procedures, safety precautions, interactions, or observed effects. These products are supplied strictly for laboratory and research purposes only. They are not intended for human consumption, medical use, veterinary use, or diagnostic purposes. This information must not be considered a substitute for professional expertise, judgment, or regulatory guidance.

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SEQUENCE/FORMULA

Sequence Formula: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg Molecular Formula: C101H152N28O22S2

MOLECULAR WEIGHT

2174.64g/mol

PUBCHEM CID

135548679
  • Investigating its role in balancing metabolism and improving how the body uses sugar
  • Analyzing its potential to enhance physical performance and endurance
  • Studying its connection to healthy aging and longevity
  • Researching its potential to support bone health
  • Exploring how it helps cells communicate and function efficiently
  • MOTS-c is a mitochondria-derived peptide (MDP), meaning it is one of the few peptides encoded by the mitochondrial genome rather than the nuclear genome.
  • It functions as a mitokine, a signaling molecule that travels from the mitochondria to the rest of the cell, including the nucleus, to regulate gene expression and cellular function.
  • A primary mechanism is the activation of the AMPK (AMP-activated protein kinase) pathway. AMPK is a master regulator of cellular energy, and its activation by MOTS-c helps increase glucose uptake and fatty acid oxidation (fat burning).
  • By promoting metabolic flexibility and efficiency, MOTS-c helps restore cellular balance, especially under conditions of metabolic stress.
  • Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443-454.
  • Reynolds, J. C., et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and systemic insulin sensitivity. Nature Communications, 12(1), 470.
  • Du, C., et al. (2017). The mitochondrial-derived peptide MOTS-c protects against cisplatin-induced renal toxicity. The FASEB Journal, 31(11), 4749-4760.
  • Lu, H., et al. (2019). MOTS-c: a novel mitochondrial-derived peptide regulating muscle and fat metabolism. The Journal of Molecular Endocrinology, 63(1), R1-R8.