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SEMA 5MG

Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It is extensively researched for its efficacy in glycemic control for type 2 diabetes and for significant weight loss in obesity studies.

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Original price was: $150.00.Current price is: $90.00.

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The information provided on this page is intended solely as a general summary. It does not encompass all potential research applications, handling procedures, safety precautions, interactions, or observed effects. These products are supplied strictly for laboratory and research purposes only. They are not intended for human consumption, medical use, veterinary use, or diagnostic purposes. This information must not be considered a substitute for professional expertise, judgment, or regulatory guidance.

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SEQUENCE/FORMULA

Sequence: His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly Molecular Formula:

MOLECULAR WEIGHT

4113.6 g/mol

PUBCHEM CID

56843331
  • Studying its effects on managing blood sugar and insulin levels
  • Investigating its role in reducing appetite and supporting weight loss
  • Analyzing its potential benefits for heart health
  • Researching its effects on liver health
  • Exploring its potential to protect brain cells
  • Semaglutide is a potent GLP-1 (glucagon-like peptide-1) receptor agonist. It mimics the function of the natural incretin hormone GLP-1 that is released from the gut after eating.
  • It works in a glucose-dependent manner to:
    • Stimulate insulin secretion from the pancreas when blood sugar levels are high.
    • Inhibit glucagon release, which prevents the liver from producing excess sugar.
    • Slow down gastric emptying, which helps manage post-meal blood sugar spikes and increases the feeling of fullness.
    • Act on centers in the brain to reduce appetite, curb food cravings, and promote satiety.
  • The molecule is structurally modified to resist degradation by the DPP-4 enzyme and to bind to albumin in the bloodstream. This gives it a very long half-life of approximately one week, allowing for once-weekly administration.
  • Marso, S. P., et al. (2016). Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. The New England Journal of Medicine, 375(19), 1834-1844.
  • Wilding, J. P. H., et al. (2021). Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine, 384(11), 989-1002.
  • Knudsen, L. B., & Lau, J. (2019). The discovery and development of liraglutide and semaglutide. Frontiers in Endocrinology, 10, 155.
  • Aroda, V. R., et al. (2019). PIONEER 1: randomized clinical trial of oral semaglutide versus placebo in patients with type 2 diabetes. Diabetes Care, 42(9), 1724-1732.